Muddy Waters is mostly associated with his candy apple red Fender Telecaster (which he called "The Hoss"). It wasn't always red though; it started out as a 50's color white blonde, maple neck Telecaster. Later he got new neck from Fender, this time in rosewood, and got the color changed to a 60's candy apple red, and changed the standard knobs to amp knobs.
Ever since the late 50's until his death in 1983, Muddy only used this guitar (with one major exception being when he played a Guild briefly for advertising purposes).
The Fender Custom Shop released a tribute to that guitar, in 2000:
After that, Fender released a standard version (Made in Mexico) for about over 10 years, and it was sadly discontinued sometime in 2008/2009.
Here's a video of Muddy playing his unique slide guitar on his Telecaster, (solo starts at 2:25)